PF-5274857

Cat. No.: OB0225WX-2516

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: PF-5274857 is a brain-penetrable Smoothened (Smo) antagonist that potently inhibits Hedgehog (Hh) signaling with a Ki of 4.6 nM.

Synonym: 1373615-35-0; 1-(4-(5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one; PF-5274857 freebase; 1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one; 1-(4-(5'-chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one; 1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one; 1-[4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl]-3-(methylsulfonyl)propan-1-one; 1-[4-(5'-Chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)piperazin-1-yl]-3-(methanesulfonyl)propan-1-one

CAS No.: 1373615-35-0

Compound CID: 56956240

Formula: C₂₀H₂₅ClN₄O₃S

Formula Weight: 436.96

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: PF-5274857 is employed in developmental biology research as a potent and selective Smoothened (Smo) antagonist to investigate the inhibition of the Hedgehog signaling pathway in tissue patterning.