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GSK-3β inhibitor 3
Cat. No.:
OB0225WX-2145
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
GSK-3β inhibitor 3 is a selective and irreversible covalent inhibitor of glycogen synthase kinase 3β (GSK-3β) featuring a half-maximal inhibitory concentration (IC50) of 6.6 μM.
Synonym:
GSK-3beta inhibitor 3; GSK-3|A inhibitor 3; 1448990-73-5; 2-(4-fluorophenyl)-5-prop-2-enoyl-2,3-dihydro-1,5-benzothiazepin-4-one; 5-acryloyl-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one; 5-Acryloyl-2,3-dihydro-2-(4-fluorophenyl)-1,5-benzothiazepin-4(5H)-one
CAS No.:
1448990-73-5
Compound CID:
155925848
Formula:
C18H14FNO2S
Formula Weight:
327.37
Specification
Targets&IC50:
GSK-3β: 6.6 μM (IC50)
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GSK-3 beta inhibitor 3 is utilized in laboratory studies as a selective chemical tool to examine the specific role of the GSK-3 beta isoform in glucose metabolism and neuronal survival pathways.
Library Information
Target:
GSK-3
Receptor:
GSK-3β
Pathways:
Stem cells; PI3K/Akt/mTOR signaling; Apoptosis
Plate Number:
AOCL-28
Plate Location:
d10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
225.0 mg/mL; 687.3 mM
