Products
Online Inquiry
PNU-74654
Cat. No.:
OB0225WX-1692
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
PNU 74654 is a β-catenin-binding compound (Kd = 450 nM) that disrupts the Wnt signaling architecture by preventing the interaction between β-catenin and the transcription factor Tcf4.
Synonym:
113906-27-7; Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide; PNU 74654; CHEMBL254381; N-[(E)-(5-Methylfuran-2-yl)methylideneamino]-2-phenoxybenzamide; PNU74654; (E)-N'-((5-methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide; MFCD12912438; 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide; N'-((5-methylfuran-2-yl)methylene)-2-phenoxybenzohydrazide
CAS No.:
113906-27-7
Compound CID:
9836739
Formula:
C19H16N2O3
Formula Weight:
320.34
Specification
Targets&IC50:
Wnt/β-catenin (NCI-H295 cells): 129.8 μM
Relative Density:
1.17 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PNU-74654 is applied in molecular biology to investigate the disruption of the interaction between beta-catenin and TCF transcription factors, specifically to study the suppression of Wnt-driven gene expression.
Library Information
Target:
Wnt/β-Catenin
Receptor:
Wnt; β-Catenin
Pathways:
Stem cells; Apoptosis; Cytoskeletal signaling
Plate Number:
AOCL-22
Plate Location:
f7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
30 mg/mL; 93.65 mM
ALogP:
3.784
HBA_Count:
4
HBD_Count:
1
Rotatable Bond:
5
