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GSK-3β inhibitor 1
Cat. No.:
OB0225WX-2134
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
GSK-3β inhibitor 1 is a potent small molecule antagonist of GSK-3-beta with an IC50 of 4.9 nM, exhibiting significant antidiabetic biochemical efficacy.
Synonym:
3367-88-2; GSK-3beta inhibitor 1; (E/Z)-GSK-3|A inhibitor 1; GSK-3|A inhibitor 1; 3-(Pyridin-2-ylmethylene)indolin-2-one; (E/Z)-GSK-3beta inhibitor 1; 3-[(2-Pyridinyl)methylene]indolin-2-one; 3-(pyridin-2-ylmethylidene)-1,3-dihydro-2h-indol-2-one; 3-(2-Pyridinylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(2-pyridinylmethylene)-1,3-dihydro-2H-indol-2-one
CAS No.:
187325-53-7
Compound CID:
5796182
Formula:
C14H10N2
Formula Weight:
222.24
Specification
Targets&IC50:
GSK-3β: 4.9 nM
Relative Density:
1.291 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GSK-3 beta inhibitor 1 is applied in stem cell and neurobiology research as a specialized chemical tool to investigate the inhibition of Glycogen Synthase Kinase 3 beta and its impact on the Wnt/beta-catenin pathway.
Library Information
Target:
GSK-3
Receptor:
GSK-3β
Pathways:
Stem cells; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-28
Plate Location:
c9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
30 mg/mL; 134.99 mM
