SB 415286

Cat. No.: OB0225WX-2143

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, HPLC, and LC-MS.

Size:

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Product Overview

Description: SB 415286 is a potent antagonist of GSK3α (IC50: 78 nM; Ki: 31 nM) that demonstrates equivalent inhibitory efficacy toward the GSK-3β isoform.

Synonym: SB415286; 264218-23-7; SB-415286; SB415286; 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione; 1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione; 3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)pyrrole-2,5-dione; 3-((3-chloro-4-hydroxyphenyl)amino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione; 3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phenyl)-pyrrole-2,5-dione; 3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione; 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)pyrrole-2,5-dione; 1H-Pyrrole-2,5-dione,3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-; 3-[(3-chloro-4-hydroxyphenyl)-amino]-4-(2-nitrophenyl)-1h-pyrrol-2,5-dione; 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1 H-pyrrole-2,5-dione; 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione

CAS No.: 264218-23-7

Compound CID: 4210951

Formula: C₁₆H₁₀ClN₃O₅

Formula Weight: 359.72

Specification

Targets&IC50: GSK-3β: 31 nM(ki); GSK-3α: 78 nM

Relative Density: 1.647 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: SB 415286 is employed in cell biology research as a potent, ATP-competitive inhibitor of GSK-3 to investigate the stimulation of glycogen synthesis and the stabilization of beta-catenin in various cell lines.