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1-Azakenpaullone
Cat. No.:
OB0225WX-2150
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
1-Azakenpaullone is a high-potency GSK-3β inhibitor (IC50: 18 nM) that exhibits over 100-fold selectivity compared to CDK5/p25 and CDK1/cyclin B.
Synonym:
Azakenpaullone; 676596-65-9; 1-AKP; 9-bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one; 9-bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one; 9-bromo-7,12-dihydropyrido(3',2':2,3)azepino(4,5-b)indol-6(5H)-one
CAS No.:
676596-65-9
Compound CID:
6538897
Formula:
C15H10BrN3
Formula Weight:
328.16
Specification
Targets&IC50:
GSK-3β: 18 nM
Relative Density:
1.655 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
1-Azakenpaullone is applied in regenerative medicine to study the enhancement of cardiomyocyte proliferation and the activation of neurogenic pathways by selectively blocking GSK-3 beta activity.
Library Information
Target:
GSK-3
Receptor:
GSK-3β
Pathways:
Stem cells; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-28
Plate Location:
e5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 182.84 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
