Gandotinib

Cat. No.: 0225LY-1365

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: LY2784544 is a potent inhibitor of JAK2 (IC50: 3 nM) that is particularly effective against the JAK2V617F mutation (Ki: 0.245 nM), offering 8- to 20-fold higher selectivity over other JAK family members.

Synonym: LY2784544; 1229236-86-5; LY 2784544; LY-2784544; 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine; 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(3-methyl-1H-pyrazol-5-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine; Imidazo[1,2-b]pyridazin-6-amine, 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)-; 3-((4-Chloro-2-fluorophenyl)methyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8- (morpholin-4-ylmethyl)imidazo(1,2-b)pyridazin-6-amine; 3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8- (morpholinomethyl)imidazo(1,2-b)pyridazin-6-amine; 3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine; Imidazo(1,2-b)pyridazin-6-amine, 3-((4-chloro-2-fluorophenyl)methyl)-2-methyl-N-(5- methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)-

CAS No.: 1229236-86-5

Compound CID: 46213929

Formula: C₂₃H₂₅ClFN₇

Formula Weight: 469.94

Specification

Targets&IC50: JAK2: 3 nM; JAK2 (V617F): 0.245 nM(Ki)

Relative Density: 1.45 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Gandotinib can be used in hematological research to study the potent inhibition of JAK2 and its role in treating myeloproliferative disorders.