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Dorsomorphin
Cat. No.:
OB0225LY-0195
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Product Overview
Description:
Dorsomorphin is a small molecule compound that acts primarily as an antagonist of the BMP (bone morphogenetic protein) signaling pathway. It affects cell proliferation and differentiation by inhibiting the Smad signaling pathway.
Synonym:
BML-275; 866405-64-3; 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; 4-(6-{4-[2-(Piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine; 6-(4-(2-(1-Piperidinyl)ethoxy)phenyl)-3-(4-pyridinyl)pyrazolo(1,5-a)pyrimidine; 4-(6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)pyridine; Pyrazolo(1,5-a)pyrimidine, 6-(4-(2-(1-piperidinyl)ethoxy)phenyl)-3-(4-pyridinyl)-
CAS No.:
866405-64-3
Compound CID:
11524144
Formula:
C24H25N5O
Formula Weight:
399.49
Specification
Relative Density:
1.255 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Dorsomorphin can be used to study the regulatory mechanisms of the BMP signaling pathway or play an important role in stem cell differentiation and bone regeneration studies.
Library Information
Targets:
Autophagy; AMPK; TGF-beta/Smad
Receptors:
ALK2; ALK3; ALK6
Pathways:
Stem cells; PI3K/Akt/mTOR signaling; Chromatin/Epigenetic; Autophagy
Plate Number:
AOCL-3
Plate Location:
d9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
2 mM DMSO
DMSO Max Solubility:
1.33 mg/mL; 3.34 mM
Solubility:
10% DMSO+90% Saline: 0.13 mg/mL (0.33 mM)
ALogP:
3.028
HBA_Count:
4
HBD_Count:
0
Rotatable Bond:
6





