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JK184
Cat. No.:
OB0225WX-2185
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
JK184 is a potent small molecule that exerts its biological effects by acting as a specific inhibitor of the Hedgehog (Hh) signaling pathway.
Synonym:
315703-52-7; N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine; JK 184; JK-184; N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine; Hh Signaling Antagonist VII, JK184; N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine; N-(4-Ethoxyphenyl)-4-(2-methylimidazo-[1,2-a]pyridin-3-yl)thiazol-2-amine; 2-Thiazolamine, N-(4-ethoxyphenyl)-4-(2-methylimidazo(1,2-a)pyridin-3-yl)-; N-(4-Ethoxyphenyl)-4-(2-methylimida zo[1,2-a]pyridin-3-yl)-2-thiazolamine
CAS No.:
315703-52-7
Compound CID:
1069686
Formula:
C19H18N4OS
Formula Weight:
350.44
Specification
Targets&IC50:
Hedgehog: 30 nM
Relative Density:
1.3 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
JK184 is employed in developmental biology as a specialized Hedgehog signaling pathway inhibitor to investigate the disruption of the Gli-mediated transcriptional response in tissue patterning.
Library Information
Target:
Hedgehog/Smoothened
Receptor:
Hedgehog
Pathways:
Stem cells; GPCR/G protein signaling
Plate Number:
AOCL-28
Plate Location:
h10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
2mM DMSO
DMSO Max Solubility:
3.5 mg/mL; 10 mM
ALogP:
4.108
HBA_Count:
3
HBD_Count:
1
Rotatable Bond:
5
