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Ritlecitinib
Cat. No.:
0225LY-1361
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Ritlecitinib is an orally bioavailable, selective JAK3 inhibitor with an IC50 of 33.1 nM that does not interfere with the activities of JAK1 or JAK2.
Synonym:
PF-06651600; 1792180-81-4; 2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-; 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one; 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one; 1-((2S,5R)-2-methyl-5-((7H-pyrrolo(2,3-d)pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one; 1-((2S,5R)-2-methyl-5-(7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one; 1-[(2S,5R)-2-methyl-5-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)piperidin-1-yl]prop-2-en-1-one
CAS No.:
1792180-81-4
Compound CID:
118115473
Formula:
C15H19N5
Formula Weight:
285.34
Specification
Targets&IC50:
JAK3: 33.1 nM (cell free)
Relative Density:
1.272 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Ritlecitinib can be used in immunology to study the irreversible inhibition of JAK3 and the TEC family of kinases.
Library Information
Target:
JAK3
Receptor:
JAK3
Pathways:
JAK/STAT signaling; Stem cell regulation; Angiogenesis; Chromatin/Epigenetic
Plate Number:
AOCL-18
Plate Location:
d11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
130 mg/mL; 455.6 mM
ALogP:
1.854
HBA_Count:
3
HBD_Count:
2
Rotatable Bond:
3





