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Vitamin B12 test kit

Ritlecitinib

Cat. No.: 0225LY-1361
Purity: ≥99%
Identity: Confirmed by NMR, and HPLC.
Size:
Ritlecitinib
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Product Overview

Description: Ritlecitinib is an orally bioavailable, selective JAK3 inhibitor with an IC50 of 33.1 nM that does not interfere with the activities of JAK1 or JAK2.
Synonym: PF-06651600; 1792180-81-4; 2-Propen-1-one, 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-; 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one; 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one; 1-((2S,5R)-2-methyl-5-((7H-pyrrolo(2,3-d)pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one; 1-((2S,5R)-2-methyl-5-(7H-pyrrolo(2,3-d)pyrimidin-4-ylamino)piperidin-1-yl)prop-2-en-1-one; 1-[(2S,5R)-2-methyl-5-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)piperidin-1-yl]prop-2-en-1-one
CAS No.: 1792180-81-4
Compound CID: 118115473
Formula: C15H19N5
Formula Weight: 285.34

Specification

Targets&IC50: JAK3: 33.1 nM (cell free)
Relative Density: 1.272 g/cm3
Stability: 3 years in powder form.
Storage: Storage at -20°C.
Applications: Ritlecitinib can be used in immunology to study the irreversible inhibition of JAK3 and the TEC family of kinases.

Library Information

Target: JAK3
Receptor: JAK3
Pathways: JAK/STAT signaling; Stem cell regulation; Angiogenesis; Chromatin/Epigenetic
Plate Number: AOCL-18
Plate Location: d11
Empty Location: a1-h1; a12-h12
Container: 96-well plate
Formulation: 10mM DMSO
DMSO Max Solubility: 130 mg/mL; 455.6 mM
ALogP: 1.854
HBA_Count: 3
HBD_Count: 2
Rotatable Bond: 3
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