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KY1220
Cat. No.:
OB0225WX-1691
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
KY1220 is a small molecule that targets the Wnt/β-catenin pathway to induce the simultaneous destabilization of Ras and β-catenin, yielding an IC50 of 2.1 μM in HEK293 reporter cell lines.
Synonym:
292168-79-7; (Z)-5-((1-(4-nitrophenyl)-1H-pyrrol-2-yl)methylene)-2-thioxoimidazolidin-4-one; (5Z)-5-[[1-(4-nitrophenyl)pyrrol-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-one; 5-((1-(4-Nitrophenyl)-1H-pyrrol-2-yl)methylene)-2-thioxoimidazolidin-4-one; (5Z)-5-{[1-(4-nitrophenyl)-1H-pyrrol-2-yl]methylidene}-2-sulfanylideneimidazolidin-4-one
CAS No.:
292168-79-7
Compound CID:
6011878
Formula:
C14H10N4O3S
Formula Weight:
314.32
Specification
Targets&IC50:
Wnt/β-catenin: 2.1 μM
Relative Density:
1.54 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
KY1220 is utilized in oncological research as a small molecule tool to study the destabilization of beta-catenin and the subsequent inhibition of the Wnt/beta-catenin signaling axis in various cancer models.
Library Information
Target:
Wnt/β-Catenin
Receptor:
Wnt/β-Catenin
Pathways:
Stem cells; Cytoskeletal signaling
Plate Number:
AOCL-22
Plate Location:
f6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
100 mg/mL; 318.15 mM
