Afuresertib hydrochloride

Cat. No.: 0225LY-1090

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Afuresertib hydrochloride is a potent Akt kinase inhibitor with Kis of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3.

Synonym: 1047645-82-8; Afuresertib (hydrochloride); 2-Thiophenecarboxamide, N-((1S)-2-amino-1-((3-fluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-, hydrochloride (1:1); N-((S)-1-Amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride; N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide;hydrochloride

CAS No.: 1047645-82-8

Compound CID: 46843056

Formula: C₁₈H₁₈Cl₃FN₄OS

Formula Weight: 463.8

Specification

Targets&IC50: Akt3: 2.6 nM(Ki); Akt2: 2 nM(Ki); Akt1: 0.08 nM(Ki)

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Afuresertib hydrochloride can be used in clinical oncology research to investigate the potent inhibition of AKT isoforms in solid tumors.