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SKL2001
Cat. No.:
OB0225WX-1705
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
SKL2001 acts as an agonist of the Wnt/β-catenin pathway by specifically disrupting the protein-protein interaction between axin and β-catenin.
Synonym:
909089-13-0; SKL 2001; 5-(furan-2-yl)-N-(3-imidazol-1-ylpropyl)-1,2-oxazole-3-carboxamide; SKL2001 free base; N-(3-(1H-imidazol-1-yl)propyl)-5-(furan-2-yl)isoxazole-3-carboxamide; SKL-2001; Wnt Agonist II; MFCD14733081; 5-Furan-2-yl-isoxazole-3-carboxylic acid (3-imidazol-1-yl-propyl)-amide
CAS No.:
909089-13-0
Compound CID:
16003447
Formula:
C14H14N4O3
Formula Weight:
286.29
Specification
Relative Density:
1.37 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SKL2001 is used in molecular pharmacology as an agonist that stabilizes beta-catenin to study the promotion of Wnt-responsive gene transcription without inhibiting GSK-3-beta.
Library Information
Target:
Wnt/β-Catenin
Receptor:
Wnt; β-Catenin
Pathways:
Stem cells; Cytoskeletal signaling
Plate Number:
AOCL-22
Plate Location:
g10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
50 mg/mL; 174.65 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
53 mg/mL; 185.1 mM
ALogP:
0.929
HBA_Count:
5
HBD_Count:
1
Rotatable Bond:
6
