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Jervine
Cat. No.:
0225LY-0546
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
Jervine exerts its biological effects by interacting with the seven-pass transmembrane protein Smoothened; by binding to and inhibiting this integral component of the Hedgehog pathway, it prevents GLI1 activation and the subsequent transcription of Hedgehog target genes.
Synonym:
Iervin; 11-Ketocyclopamine; Jerwiny; 469-59-0; (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3-Hydroxy-3',6',10,11b-tetramethylspiro[1,2,3,4,6,6a,6b,7,8,11a-decahydrobenzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-11-one
CAS No.:
469-59-0
Compound CID:
10098
Formula:
C27H39NO3
Formula Weight:
425.6
Specification
Targets&IC50:
Hedgehog: 500-700 nM (IC50)
Relative Density:
1.18 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Jervine can be used in embryology research to study its effects on Sonic hedgehog signaling and cholesterol biosynthesis.
Library Information
Target:
Smo
Receptor:
Smo
Pathways:
Hedgehog signaling; Stem cell regulation; Developmental biology
Plate Number:
AOCL-8
Plate Location:
a10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
4.26 mg/mL; 10.01 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
ALogP:
3.472
HBA_Count:
2
HBD_Count:
2
Rotatable Bond:
0
