CHIR-124

Cat. No.: 0225LY-1104

Appearance: Solid

Purity: ≥98%

Identity: Confirmed by NMR.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: CHIR-124 serves as an efficient Chk1 inhibitor with an IC50 of 0.3 nM, providing 2,000-fold selectivity over Chk2 and significantly lower potency against CDK2/4 and Cdc2.

Synonym: CHIR124; CHIR 124; 405168-58-3; (S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one; 4-[(3s)-1-Azabicyclo[2.2.2]oct-3-Ylamino]-3-(1h-Benzimidazol-2-Yl)-6-Chloroquinolin-2(1h)-One; 2(1H)-Quinolinone, 4-((3S)-1-azabicyclo(2.2.2)oct-3-ylamino)-3-(1H-benzimidazol-2-yl)-6-chloro-; 4-(((3S)-1-Azabicyclo(2.2.2)oct-3-yl)amino)-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one; 4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-6-chloro-3-(1,3-dihydrobenzimidazol-2-ylidene)quinolin-2-one

CAS No.: 405168-58-3

Compound CID: 135399748

Formula: C₂₃H₂₂ClN₅

Formula Weight: 419.91

Specification

Targets&IC50: Chk1: 0.3 nM

Relative Density: 1.46 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: CHIR-124 can be used in cell cycle research to study the selective inhibition of Chk1 and its potential in sensitizing tumor cells to DNA-damaging agents.