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KYA1797K
Cat. No.:
OB0225WX-1717
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
KYA1797K is a high-selectivity inhibitor that suppresses Wnt/β-catenin signaling with an IC50 of 0.75 μM, as determined by TOPflash reporter assays.
Synonym:
1956356-56-1; KYA 1797K; potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate; Potassium;3-[(5Z)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoate
CAS No.:
1956356-56-1
Compound CID:
119057297
Formula:
C17H11N2O6S2·K
Formula Weight:
442.51
Specification
Targets&IC50:
Wnt/β-catenin: 0.75 μM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
KYA1797K is utilized in pharmacological studies to investigate the simultaneous degradation of beta-catenin and Ras, specifically to study the suppression of tumor growth in mutant-driven models.
Library Information
Target:
Wnt/β-Catenin
Receptor:
Wnt; β-Catenin
Pathways:
Stem cells; Cytoskeletal signaling
Plate Number:
AOCL-23
Plate Location:
a2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
6 mg/mL; 13.56 mM
ALogP:
3.967
HBA_Count:
4
HBD_Count:
0
Rotatable Bond:
7
