XAV-939

Cat. No.: OB0225WX-1693

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

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Product Overview

Description: XAV-939 is a selective tankyrase (TNKS) inhibitor with IC50 values of 11 nM for TNKS1 and 4 nM for TNKS2, resulting in the suppression of Wnt/β-catenin-mediated transcriptional activity.

Synonym: XAV939; NVP-XAV939; 284028-89-3; 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one; XAV 939; 2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol; 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol; 2-[4-(trifluoromethyl)phenyl]-5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-ol; 2-[4-(Trifluoromethyl)phenyl]-7,8-Dihydro-5h-Thiopyrano[4,3-D]pyrimidin-4-Ol; NVP-XAV-939; 2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one; NVP-XAV 939; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiino(4,3-d)pyrimidin-4-ol; MFCD16879017; 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one; 2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano-[4,3-d]pyrimidin-4-ol; 2-[4-(trifluoromethyl)phenyl]-1H,4H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one; 2-[4-(trifluoromethyl)phenyl]-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one; 4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4-(trifluoromethyl)phenyl]-

CAS No.: 284028-89-3

Compound CID: 135418940

Formula: C₁₄H₁₁F₃N₂OS

Formula Weight: 312.31

Specification

Targets&IC50: TNKS1: 11 nM (cell free); TNKS2: 4 nM (cell free)

Relative Density: 1.5 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: XAV-939 is employed in cell signaling research as a selective tankyrase inhibitor to study the stabilization of axin and the promotion of beta-catenin degradation.