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A 1070722
Cat. No.:
OB0225WX-2160
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
A 1070722 is a potent, brain-penetrant GSK-3 inhibitor possessing high and equal affinity for both GSK-3α and GSK-3β isoforms (Ki = 0.6 nM).
Synonym:
1384424-80-9; 1-(7-methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea; A-1070722; 1-(7-methoxyquinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)urea
CAS No.:
1384424-80-9
Compound CID:
49830684
Formula:
C17H13F3N4O2
Formula Weight:
362.31
Specification
Targets&IC50:
GSK-3β: 0.6 nM (ki); GSK-3α: 0.6 nM (ki)
Relative Density:
1.461 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
A 1070722 is employed in neuropharmacology to investigate the selective inhibition of GSK-3 and its impact on the modulation of mood-related signaling and neurotransmitter release.
Library Information
Target:
GSK-3
Receptor:
GSK-3α; GSK-3β
Pathways:
Stem cells; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-28
Plate Location:
f5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
83.33 mg/mL; 230.00 mM
