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NM-3
Cat. No.:
OB0225WX-1998
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
NM-3 is an anti-angiogenic small molecule that inhibits vascular endothelial growth factor (VEGF), thereby suppressing endothelial cell proliferation through a reactive oxygen species-dependent apoptotic mechanism.
Synonym:
Isocoumarin; NM 3; Isocoumarin NM-3; NM3; 181427-78-1; NM 3 (isocoumarin); NM-3 (isocoumarin); NM 3; 2-(8-hydroxy-6-methoxy-1-oxoisochromen-3-yl)propanoic acid; 2-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propanoic acid; 2-(8-Hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propionic acid; 5797K23F95; 1H-2-Benzopyran-3-acetic acid, 8-hydroxy-6-methoxy-alpha-methyl-1-oxo-; 8-Hydroxy-6-methoxy-alpha-methyl-1-oxo-1H-2-benzopyran-3-acetic acid; 2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid; 2-(8-Hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl)propanoic acid
CAS No.:
181427-78-1
Compound CID:
5493470
Formula:
C13H12O6
Formula Weight:
264.23
Specification
Relative Density:
1.434 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
NM-3 is employed in cardiovascular and oncology research as an orally active isocoumarin to study the inhibition of angiogenesis and the suppression of vascular endothelial growth factor (VEGF) signaling.
Library Information
Target:
Reactive oxygen species
Receptor:
Reactive oxygen species
Pathways:
Metabolism; Apoptosis; NF-κB; Immunology/Inflammation
Plate Number:
AOCL-26
Plate Location:
e11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
27.5 mg/mL; 104.08 mM
