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ML348
Cat. No.:
OB0225WX-2088
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
ML348 is a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1) featuring a half-maximal inhibitory concentration (IC50) of 210 nM.
Synonym:
GNF-Pf-1127; 899713-86-1; ML 348; GNF-Pf-1127; N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(furan-2-carbonyl)piperazin-1-yl]acetamide; N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide; N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide; N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide; ML-348; N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(furan-2-ylcarbonyl)piperazin-1-yl]acetamide
CAS No.:
899713-86-1
Compound CID:
3238952
Formula:
C18H17ClF3N3O3
Formula Weight:
415.79
Specification
Targets&IC50:
LYPLA1: 210 nM
Relative Density:
1.422 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ML348 is employed in molecular pharmacology as a selective and reversible inhibitor of the enzyme 15-lipoxygenase-1 (15-LOX-1) to study its specific role in lipid peroxidation and ferroptosis.
Library Information
Target:
Phospholipase
Receptor:
LYPLA1
Pathways:
Metabolism
Plate Number:
AOCL-27
Plate Location:
f11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
83.33 mg/mL; 200.41 mM
