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A-769662
Cat. No.:
OB0225LY-0020
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR and HPLC.
Size:
Product Overview
Description:
A-769662 is a potent and reversible activator of AMPK, suggesting potential therapeutic applications.
Synonym:
844499-71-4; 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile; 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno(2,3-b)pyridine-5-carbonitrile; Thieno(2,3-b)pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy(1,1'-biphenyl)-4-yl)-6-oxo-; 6-Hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-4-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile; 4-Hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile; Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-
CAS No.:
844499-71-4
Compound CID:
54708532
Formula:
C20H12N2O3S
Formula Weight:
360.39
Specification
Relative Density:
1.56 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
A-769662 is a high-affinity AMPK activator that enhances cellular energy metabolism by increasing ACC phosphorylation and reducing fatty acid synthesis.
Library Information
Targets:
AMPK; Metabolic enzymes
Receptors:
AMPK; FAS
Pathways:
Metabolism; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-1
Plate Location:
b11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
45 mg/mL; 124.86 mM
Ethanol Max Solubility:
3.6 mg/mL; 10 mM
ALogP:
3.135
HBA_Count:
1
HBD_Count:
3
Rotatable Bond:
2
