AZD7545

Cat. No.: OB0225WX-2692

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

Add to basket

Product Overview

Description: AZD7545 is a potent antagonist of pyruvate dehydrogenase kinase (PDHK), exhibiting IC50 values of 36.8 nM and 6.4 nM for the PDHK1 and PDHK2 isoforms, respectively.

Synonym: 252017-04-2; AZD-7545; 4-[(3-Chloro-4-{[(2r)-3,3,3-Trifluoro-2-Hydroxy-2-Methylpropanoyl]amino}phenyl)sulfonyl]-N,N-Dimethylbenzamide; AZD 7545; 4-{3-chloro-4-[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamido]benzenesulfonyl}-N,N-dimethylbenzamide; (R)-4-((3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)sulfonyl)-N,N-dimethylbenzamide; 4-[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoyl]amino]phenyl]sulfonyl-N,N-dimethylbenzamide; Benzamide, 4-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-; 4-[[3-chloro-4-[[(2R)-3,3,3-trifluoro-2-hydroxy-2-methyl-1-oxopropyl]amino]phenyl]sulfonyl]-N,N-dimethyl-benzamide; MFCD25976792; (R)-4-(3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenylsulfonyl)-N,N-dimethylbenzamide

CAS No.: 252017-04-2

Compound CID: 16741245

Formula: C₁₉H₁₈ClF₃N₂O₅S

Formula Weight: 478.87

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: AZD7545 is used in metabolic disease research as a potent and selective PDHK inhibitor to investigate the enhancement of pyruvate dehydrogenase complex activity and its role in improving glucose oxidation.