PF-05221304

Cat. No.: OB0225WX-1680

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, HPLC, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: PF-05221304 is a liver-targeted, orally active inhibitor of acetyl-CoA carboxylase (ACC), a critical rate-limiting enzyme in the biosynthesis of long-chain fatty acids.

Synonym: STAT5 Inhibitor III; NSC 170984; R 6238,;Clesacostat; 1370448-25-1; PF05221304; Benzoic acid, 4-(6-methoxy-4-((1,4,6,7-tetrahydro-1-(1-methylethyl)-7-oxospiro(5H-indazole-5,4'-piperidin)-1'-yl)carbonyl)-2-pyridinyl)-; Benzoic acid, 4-[6-methoxy-4-[[1,4,6,7-tetrahydro-1-(1-methylethyl)-7-oxospiro[5H-indazole-5,4'-piperidin]-1'-yl]carbonyl]-2-pyridinyl]-; 4-[6-methoxy-4-(7-oxo-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-1'-carbonyl)pyridin-2-yl]benzoic acid; 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid; 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoicacid; 4-(6-Methoxy-4-(7-oxo-1-(propan-2-yl)-1,4,6,7-tetrahydrospiro(indazole-5,4'- piperidine)-1'-carbonyl)pyridin-2-yl)benzoic acid; 4-[4-({1-isopropyl-7-oxo-4,6-dihydrospiro[indazole-5,4'-piperidin]-1'-yl}carbonyl)-6-methoxypyridin-2-yl]benzoic acid; 4-[6-Methoxy-4-[[1,4,6,7-tetrahydro-1-(1-methylethyl)-7-oxospiro[5H-indazole-5,4'-piperidin]-1'-yl]carbonyl]-2-pyridinyl]benzoic acid

CAS No.: 1370448-25-1

Compound CID: 57496611

Formula: C₂₈H₃₀N₄O₅

Formula Weight: 502.56

Specification

Relative Density: 1.36 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: PF-05221304 is employed in hepatology research as a potent, liver-targeted ACC inhibitor to study the reduction of hepatic steatosis and the treatment of non-alcoholic fatty liver disease.