LGK-974

Cat. No.: OB0225WX-2669

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: LGK-974 is a specific and potent inhibitor of the PORCN enzyme, effectively disrupting Wnt signaling pathways with an IC50 of 0.4 nM in cellular assays.

Synonym: NVP-LGK974, WNT974; 1243244-14-5; LGK974; -(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide; WNT-974; LGK 974; LGK974 (WNT974); MFCD27501026; [2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-; LGK-974 (WNT974); 2-[5-Methyl-6-(2-methyl-4-pyridyl)-3-pyridyl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide; 2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide; 2-(2',3-Dimethyl-(2,4'-bipyridin)-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide; 2-(2',3-dimethyl-2,4'-bipyridin-5-yl)-N-[5-(pyrazin-2-yl)pyridin-2-yl]acetamide; 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide

CAS No.: 1243244-14-5

Compound CID: 46926973

Formula: C₂₃H₂₀N₆

Formula Weight: 396.44

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: LGK-974 is employed in developmental and cancer research as a potent and selective Porcn inhibitor to study the blockage of Wnt ligand secretion and the suppression of Wnt-driven tumor growth.