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AR-A014418
Cat. No.:
OB0225WX-2137
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
AR-A014418 is a selective, ATP-competitive inhibitor that specifically targets the GSK3-beta isoform.
Synonym:
AR 0133418; GSK-3beta Inhibitor VIII; AR 014418; GSK 3β inhibitor VIII; 487021-52-3; AR-A014418; 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea; AR-AO 14418; AR-AO-14418; AR-A 014418; GSK-3b; MFCD08277040; N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; Urea, N-((4-methoxyphenyl)methyl)-N'-(5-nitro-2-thiazolyl)-; GSK-3|A Inhibitor VIII; GSK 3beta inhibitor VIII; SN 4521; GSK-3beta inhibitor VIII AR-A014418; GSK-3b inhibitor VIII; GSK-3EC Inhibitor VIII; GSK-3 beta Inhibitor VIII; 1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea; 1-[(4-methoxyphenyl)methyl]-3-(5-nitrothiazol-2-yl)urea
CAS No.:
487021-52-3
Compound CID:
448014
Formula:
C12H12N4O4S
Formula Weight:
308.31
Specification
Targets&IC50:
GSK-3β: 38 nM(Ki)
Relative Density:
1.464 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AR-A014418 is utilized in neuroscience research as a selective GSK-3 beta inhibitor to examine its neuroprotective effects and its role in reducing tau phosphorylation in neurodegenerative models.
Library Information
Target:
GSK-3
Receptor:
GSK-3β
Pathways:
Stem cells; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-28
Plate Location:
d2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
30.8 mg/mL; 100 mM
Ethanol Max Solubility:
1.5 mg/mL; 5 mM
