Laduviglusib trihydrochloride

Cat. No.: OB0225WX-1718

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Laduviglusib trihydrochloride is a selective GSK-3 inhibitor (IC50: 10 nM for α and 6.7 nM for β) and Wnt/β-catenin activator that also functions as an inducer of cellular autophagy.

Synonym: CT99021 trihydrochloride; CHIR 99021 trihydrochloride; CHIR 99021 trihydrochloride (252917-06-9 free base); 1782235-14-6; CHIR 99021 trihydrochloride; CHIR-99021 trihydrochloride; CHIR-911 trihydrochloride; Laduviglusib (trihydrochloride); CHIR-99021 (trihydrochloride); 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile trihydrochloride; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile;trihydrochloride; 3-Pyridinecarbonitrile, 6-((2-((4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl)amino)ethyl)amino)-, hydrochloride (1:3); 6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile trihydrochloride; CT99021 trihydrochloride; 6-((2-((4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitriletrihydrochloride; 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethy l]amino]-3-pyridinecarbonitrile trihydrochloride

CAS No.: 1782235-14-6

Compound CID: 78243722

Formula: C₂₂H₂₁Cl₅N₈

Formula Weight: 573.71

Specification

Targets&IC50: GSK-3β: 6.7 nM; CDC2: 8800 nM; GSK-3α: 10 nM

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Laduviglusib trihydrochloride is applied in stem cell research as a potent GSK-3-beta inhibitor to study the activation of the canonical Wnt pathway and the modulation of lineage commitment.