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BMS-911543
Cat. No.:
0225LY-1363
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
BMS-911543 is a highly potent JAK2 inhibitor (IC50: 1.1 nM) that displays remarkable selectivity, being approximately 350-fold more selective for JAK2 than for JAK1.
Synonym:
BMS911543; 1271022-90-2; BMS 911543; N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide; Imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-; N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide; N,N-dicyclopropyl-7-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-10-ethyl-3-methyl-3,5,8,10-tetraazatricyclo(7.3.0.0^(2,6))dodeca-1,4,6,8,11-pentaene-11-carboxamide; N,N-dicyclopropyl-7-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetraazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaene-11-carboxamide
CAS No.:
1271022-90-2
Compound CID:
50922691
Formula:
C23H28N8
Formula Weight:
432.52
Specification
Targets&IC50:
TYK2: 75nM; AK1: 1.1 nM; JAK3: 350nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
BMS-911543 can be used in oncology research to evaluate the selective inhibition of JAK2 and its effects on cell proliferation.
Library Information
Target:
Tyrosine kinases; Histone methyltransferase; JAK
Receptor:
JAK1; JAK2; JAK3; SET-2; TYK2
Pathways:
Stem cell regulation; Tyrosine kinase/adaptors; Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling
Plate Number:
AOCL-18
Plate Location:
e3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
16.67 mg/mL; 38.54 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
21 mg/mL; 48.55 mM
ALogP:
3.556
HBA_Count:
4
HBD_Count:
1
Rotatable Bond:
6
