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JW 642
Cat. No.:
OB0225WX-1880
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
JW 642 functions as an effective inhibitor of monoacylglycerol lipase (MAGL), with IC50 values of 3.7 nM, 7.6 nM, and 14 nM for the human, mouse, and rat brain isoforms, respectively.
Synonym:
1416133-89-5; 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate; JW642; 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate; 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester; JW-642
CAS No.:
1416133-89-5
Compound CID:
71656520
Formula:
C21H20F6N2O3
Formula Weight:
462.39
Specification
Targets&IC50:
MAGL (human): 3.7 nM; MAGL (rat): 14 nM; MAGL (mouse): 7.6 nM
Relative Density:
1.354 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
JW 642 is applied in neuropharmacology to study the selective inhibition of monoacylglycerol lipase and the subsequent impact on cannabinoid receptor-mediated behavioral and physiological responses.
Library Information
Target:
Lipase
Receptor:
MAGL
Pathways:
Metabolism
Plate Number:
AOCL-25
Plate Location:
a11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
90 mg/mL; 194.64 mM
