ML349

Cat. No.: OB0225WX-2094

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: ML349 is a potent inhibitor of LYPLA2 (IC50: 144 nM) that also functions as an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM.

Synonym: 890819-86-0; (5,5-Dioxo-4H-thieno[3,2-c]thiochromen-2-yl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone; (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone; ML 349; 1-[(5,5-dioxido-4H-thieno[3,2-c]thiochromen-2-yl)carbonyl]-4-(4-methoxyphenyl)piperazine; 2-[4-(4-Methoxyphenyl)piperazine-1-Carbonyl]-5lambda~6~-Thieno[3,2-C][1]benzothiopyran-5,5(4h)-Dione; MFCD14808090; 2-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-4H-5-thieno[3,2-c]thiochromene-5,5-dione; 2-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-4H-5??-thieno[3,2-c]thiochromene-5,5-dione; (5,5-dioxido-4H-thieno[3,2-c]thiochromen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone; 2-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-4H-5lambda-thieno[3,2-c]thiochromene-5,5-dione

CAS No.: 890819-86-0

Compound CID: 16193817

Formula: C₂₃H₂₂N₂O₄S₂

Formula Weight: 454.56

Specification

Targets&IC50: LYPLA2: 144 nM(ki); APT2: (ki)120 nM

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: ML349 is applied in lipid research as a potent and selective inhibitor of 15-lipoxygenase-2 (15-LOX-2) to study the distinct biological functions of this enzyme compared to its 15-LOX-1 isoform.