IWP-2

Cat. No.: OB0225WX-1621

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: IWP-2 is an inhibitor of the Wnt signaling pathway with an IC50 of 27 nM, while also functioning as an ATP-competitive inhibitor of CK1δ with an IC50 of 40 nM against M82FCK1δ.

Synonym: IWP2; 686770-61-6; IWP-2; IWP 2; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide; N-(6-methylbenzo[d]thiazol-2-yl)-2-((4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamide; N-(6-Methylbenzo[d]thiazol-2-yl)-2-(4-oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-ylthio)acetamide; Wnt Inhibitor IWP-2; MFCD04457599; N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide; Inhibitor of Wnt Production-2; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]; N -(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrimidin-2-yl)thio]-acetamide; N -(6-Methyl-2-benzothiazolyl)-2-[(3a?4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2- d ]pyrimaidin-2-yl)thio]-acetamide; N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide; N-(6-Methyl-2-benzothiazolyl)-2-[(3 ,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide

CAS No.: 686770-61-6

Compound CID: 2155128

Formula: C₂₂H₁₈N₄O₂S₃

Formula Weight: 466.6

Specification

Targets&IC50: Wnt: 27 nM

Relative Density: 1.52 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: IWP-2 is utilized in regenerative medicine and cell signaling research to investigate the mechanisms of cardiomyocyte differentiation and the disruption of Wnt-mediated signaling pathways.