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A 922500
Cat. No.:
0225LY-0721
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
A 922500 inhibits human and mouse DGAT-1 with IC50s of 7 nM and 24 nM, respectively, maintaining high selectivity over other acyltransferases and hERG.
Synonym:
DGAT-1 Inhibitor 4a; 959122-11-3; Cyclopentanecarboxylic acid, 2-((4'-(((phenylamino)carbonyl)amino)(1,1'-biphenyl)-4-yl)carbonyl)-, (1R,2R)-; (1R,2R)-2-(4'-(3-phenylureido)-[1,1'-biphenyl]-4-carbonyl)cyclopentane-1-carboxylic acid; (1R,2R)-2-[4-[4-(phenylcarbamoylamino)phenyl]benzoyl]cyclopentane-1-carboxylic acid; (1R,2R)-2-(4'-(3-Phenylureido)-[1,1'-biphenyl]-4-carbonyl)cyclopentanecarboxylic acid
CAS No.:
959122-11-3
Compound CID:
24768261
Formula:
C26H24N2O4
Formula Weight:
428.48
Specification
Targets&IC50:
DGAT-1 (human): 7 nM; DGAT-1 (mouse): 24 nM
Relative Density:
1.323 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
A 922500 can be used in lipid research to examine the effects of selective DGAT1 inhibition on energy homeostasis and body weight.
Library Information
Target:
DGAT-2; DGAT-1
Receptor:
DGAT-2; DGAT-1
Pathways:
Metabolism
Plate Number:
AOCL-10
Plate Location:
c8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
73 mg/mL; 170.37 mM
ALogP:
4.636
HBA_Count:
3
HBD_Count:
2
Rotatable Bond:
6
