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XEN445
Cat. No.:
OB0225WX-1877
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
XEN445 is a selective endothelial lipase (EL) inhibitor with an IC50 of 0.237 μM, possessing favorable ADME and pharmacokinetic properties.
Synonym:
XEN 445; XEN-445; 1515856-92-4; (S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid; 2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid; 2-[(3S)-3-[(pyridin-2-yl)methoxy]pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid; MFCD28166367; N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-{[3'-(methylsulfonyl)-4-biphenylyl]methyl}benzenesulfonamide
CAS No.:
1515856-92-4
Compound CID:
72736173
Formula:
C18H17F3N2O3
Formula Weight:
366.33
Specification
Targets&IC50:
Endothelial lipase: 0.237 μM
Relative Density:
1.40 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
XEN445 is employed in metabolic research as a potent and selective inhibitor of endothelial lipase to study the regulation of plasma HDL-C levels and lipoprotein subfraction distribution.
Library Information
Target:
Lipase
Receptor:
Endothelial lipase
Pathways:
Metabolism
Plate Number:
AOCL-25
Plate Location:
a8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 163.79 mM
Ethanol Max Solubility:
36.6 mg/mL; 100 mM
ALogP:
3.725
HBA_Count:
3
HBD_Count:
0
Rotatable Bond:
6
