ND-646

Cat. No.: OB0225WX-1678

Appearance: Solid

Purity: ≥98%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: ND-646 is an allosteric and orally bioavailable inhibitor of the ACC enzymes, with IC50 values of 3.5 nM for hACC1 and 4.1 nM for hACC2, respectively.

Synonym: 1434639-57-2; 2-[1-[(2R)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanamide; 2-[1-[(2~{r})-2-(2-Methoxyphenyl)-2-(Oxan-4-Yloxy)ethyl]-5-Methyl-6-(1,3-Oxazol-2-Yl)-2,4-Bis(Oxidanylidene)thieno[2,3-D]pyrimidin-3-Yl]-2-Methyl-Propanamide; 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-alpha,alpha,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetamide; (R)-2-(1-(2-(2-methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl)-2-methylpropanamide; 2-{1-[(2R)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl}-2-methylpropanamide; 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-; 6U3

CAS No.: 1434639-57-2

Compound CID: 71570560

Formula: C₂₈H₃₂N₄O₇S

Formula Weight: 568.64

Specification

Targets&IC50: ACC2 (human): 4.1 nM ; ACC1 (human): 3.5 nM

Relative Density: 1.40 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: ND-646 is used in advanced oncological research as a non-mutagenic ACC inhibitor to study the metabolic vulnerabilities of tumors that rely on de novo lipogenesis.