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N-[1,2-Dithiolane-3-pentanoyl]-L-glutamyl-L-alanine
Cat. No.:
OB0626WX-51
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
N-[1,2-Dithiolane-3-pentanoyl]-L-glutamyl-L-alanine is a peptide-conjugated derivative of DL-alpha-lipoic acid that demonstrates robust cytoprotective properties across distinct models of acute tissue injury, reducing myocardial infarct size in rat models of myocardial infarction induced by coronary artery ligation when administered intravenously at doses of 1 or 2 mg/kg. Furthermore, it exerts significant neuroprotective effects by minimizing hemispheric brain swelling, midline structural shift, and subsequent intracerebral hemorrhaging in porcine models of traumatic brain injury (TBI) challenged via controlled cortical impact.
Synonyms:
N-[5-(1,2-dithiolan-3-yl)-1-oxopentyl]-L-α-glutamyl-L-alanine; CMX-2043; (R)-Lip-L-glu-L-ala-OH; Lip-ea; R-lip-ea-oh; R-Lipoic acid-L-glutamate-L-alanine; alpha-N-((R )-1,2-Dithiolane-3-pentanoyl)-L-glutamyl-L-alanine; N-[5-(3R)-1,2-Dithiolan-3-yl-1-oxopentyl]-L-alpha-glutamyl-L-alanine; (4S)-5-[[(1S)-1-carboxyethyl]amino]-4-[5-[(3R)-dithiolan-3-yl]pentanoylamino]-5-oxopentanoic acid; 1255918-84-3
CAS No.:
1255918-84-3
Compound CID:
49802864
Formula:
C16H26N2O6S2
Formula Weight:
406.5
Specification
Solubility in Other Solvents:
Acetonitrile:Water mixture: 0.1-1 mg/mL
Storage:
Storage at -20°C.
Applications:
N-[1,2-Dithiolane-3-pentanoyl]-L-glutamyl-L-alanine serves as a disulfide-containing peptide conjugate for investigating redox-responsive molecular properties, peptide-based assemblies, and thiol-related chemical interactions. It supports studies of peptide modification strategies, surface conjugation approaches, and characterization of redox-sensitive biomolecular materials.