GW4869

Cat. No.: OB0225WX-2083

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: GW4869 is a selective, non-competitive antagonist of neutral sphingomyelinase (N-SMase) with an IC50 of 1 μM, known for its ability to interfere with exosome release and biogenesis.

Synonym: GW554869A; GW 4869; GW69A; 6823-69-4; GW-4869 HCl; GW4869 dihydrochloride; GW-4869; (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride; GW69A; (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide;dihydrochloride; p-Benzenediacrylanilide, 4 inverted exclamation marka,4 inverted exclamation marka inverted exclamation marka-di-2-imidazolin-2-yl-, dihydrochloride; (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide; N-SMase Inhibitor; MFCD06411564; 2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, dihydrochloride; p-Benzenediacrylanilide,4invertedexclamationmarka,4invertedexclamationmarkainvertedexclamationmarka-di-2-imidazolin-2-yl-,dihydrochloride

CAS No.: 6823-69-4

Compound CID: 16078967

Formula: C₃₀H₃₀Cl₂N₆O₂

Formula Weight: 577.5

Specification

Targets&IC50: SMase: 1 μM

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: GW4869 is employed in cell biology research as a cell-permeable inhibitor of neutral sphingomyelinase (nSMase) to investigate the biogenesis of exosomes and the role of ceramide in cellular vesicle trafficking.