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Taraxerol
Cat. No.:
OB0626WX-46
Appearance:
Crystalline solid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Taraxerol is a pentacyclic triterpene isolated from Taraxacum officinale that possesses versatile biological and therapeutic activities, suppressing the proliferation of MDA-MB-468 and SK-BR-3 breast cancer cells with IC50 values of 100.5 and 84.48 µM, respectively, by inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2), accelerating the degradation of glutathione peroxidase 4 (GPX4), and triggering ferroptosis. When administered in vivo at 10 mg/kg, it significantly represses tumor growth in SK-BR-3 murine xenograft models; moreover, at concentrations of 20 and 40 µM, it effectively downregulates COX-2 and inducible nitric oxide synthase (iNOS) expressions in LPS-stimulated RAW 264.7 macrophages, leading to decreased secretion of pro-inflammatory mediators including nitrite, prostaglandin E2, IL-6, IL-1beta, and TNF-alpha. In high-fat diet and streptozotocin-induced diabetic rat models, a 20 mg/kg dose of this triterpene alleviates hyperglycemia while concurrently upregulating skeletal muscle PI3K and membrane-associated glucose transporter 4 (GLUT4) levels, alongside enhancing the phosphorylation cascades of insulin receptor substrate 1 (IRS-1), Akt, and AMP-activated protein kinase (AMPK).
Synonyms:
13α-methyl-27-norolean-14-en-3β-ol; Alnulin; Skimmiol; 3β-Taraxerol; (+)-Taraxerol; D-friedoolean-14-en-3 beta-ol; 127-22-0
CAS No.:
127-22-0
Compound CID:
92097
Formula:
C30H50O
Formula Weight:
426.7
Specification
Source:
Cyclocarya paliurus
Solubility in Other Solvents:
Chloroform: 0.1-1 mg/mL; Methanol: 0.1-1 mg/mL; Water: 0.1-1 mg/mL
Storage:
Storage at -20°C.
Applications:
Taraxerol serves as a triterpenoid reference compound for analytical characterization of plant-derived sterol-like molecules and investigation of lipid-associated molecular properties. It supports natural product analysis, structural identification workflows, and studies of hydrophobic compound interactions in lipid systems.