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Safingol
Cat. No.:
OB0626WX-2415
Appearance:
Crystalline solid
Purity:
≥98%
Identity:
Confirmed by TLC and GC.
Size:
Add to basket
Product Overview
Description:
Safingol is a specialized L-threo sphinganine diastereomer that functions as a dual inhibitor of protein kinase C and sphingosine kinase. By targeting the regulatory phorbol-binding domain of protein kinase C and blocking sphingosine-directed phosphorylation cascades, this sphingolipid derivative modulates intracellular survival networks and selectively restores chemotherapeutic sensitivity in drug-resistant carcinoma lines.
Synonyms:
(2S,3S)-2-amino1,3-octadecanediol; L-threo-Dihydrosphingosine; L-threo-Sphinganine; 2-aminooctadecane-1,3-diol; 15639-50-6
CAS No.:
15639-50-6
Compound CID:
3058739
Formula:
C18H39NO2
Formula Weight:
301.5
Specification
Solubility in Ethanol:
0.25 mg/mL
Storage:
Storage at -20°C.
Applications:
Safingol serves as a research tool for sphingolipid biochemistry and lipid signaling studies. It supports investigations of sphingolipid metabolism, ceramide-related pathways, lipid–protein interactions, and mechanistic studies in chemical biology.