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Rotenone
Cat. No.:
OB0626WX-2560
Appearance:
Crystalline solid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
Rotenone is a classical, highly lipophilic macrocyclic compound that functions as a potent, high-affinity inhibitor of complex I within the mitochondrial electron transport chain, specifically targeting NADH/DB oxidoreductase and NADH oxidase complexes. This xenobiotic probe suppresses cellular respiration, triggers mitochondrial reactive oxygen species generation, and induces selective dopaminergic cell death accompanied by cytoplasmic inclusions, making it an essential reference tool for modeling oxidative stress, mitochondrial decay, and motor function deficits.
Synonyms:
(2R,6aS,12aS)-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one; Dactinol; Paraderil; Tubatoxin; (-)-Rotenone; Derrin; Derris; Nicouline; (-)-cis-Rotenone; Deril; Liquid Derris; Cube-Pulver; Dri-Kil; Rotocide; Noxfire; Ronone; Rotenon; Canex; Rotefive; Rotefour; Rotessenol; Tubotoxin; Extrax; Haiari; Mexide; Rotenox; Cubor; Chem-Mite; Synpren; Gerane; Ro-Ko; Derris (insecticide); Pb-nox; Rotenox 5EC; 5'-beta-Rotenone; Nekoe; Rotacide E.C.; NCI-C55210; CUBE; NSC26258; NSC-26258; Rotenoid; Prentox; Caswell No. 725; Rotenone, commercial; Rotenone, dehydro; Derris resins; Rotenona; Rotenone [BSI:ISO]; Protax; 5'.beta.-Rotenone; Noxfish; 5''beta-rotenone; 5'b-Rotenone; Rotocide E.C.; Rotenone (7CI); 83-79-4
CAS No.:
83-79-4
Compound CID:
6758
Formula:
C23H22O6
Formula Weight:
394.4
Specification
λmax:
236 nm; 294 nm
Solubility in DMSO:
50 mg/mL
Solubility in Ethanol:
5 mg/mL
Solubility in Other Solvents:
Chloroform: 50 mg/mL
Storage:
Storage at -20°C.
Applications:
Rotenone is utilized in biochemical research investigating mitochondrial-associated processes and cellular energy metabolism. It serves as a research compound for studies involving mitochondrial function, oxidative stress-related mechanisms, and comparative analysis of bioactive small molecules affecting cellular metabolic pathways.