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LB100
Cat. No.:
OB0225WX-2354
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
LB100 is a water-soluble organic compound that functions as an inhibitor of protein phosphatase 2A (PP2A).
Synonym:
LB-100; LB 100; 1632032-53-1; 7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1R,4S)-rel-; (1R,4S)-3-(4-Methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid; 3-[(4-Methylpiperazin-1-yl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid; 3-((4-Methylpiperazin-1-yl)carbonyl)-7-oxabicyclo(2.2.1)heptane-2-carboxylic acid; 7-Oxabicyclo(2.2.1)heptane-2-carboxylic acid, 3-((4-methyl-1-piperazinyl)carbonyl)-, (1R,4S)-rel-; (1R,4S)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo(2.2.1)heptane-2-carboxylic acid; 3-[(4-Methylpiperazin-1-yl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
CAS No.:
1632032-53-1
Compound CID:
45101433
Formula:
C13H20N2O4
Formula Weight:
268.31
Specification
Targets&IC50:
PP2A(Panc-1): 3.87 μM; PP2A(BxPc-3): 0.85 μM
Relative Density:
1.312 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
LB100 is used in signal transduction research as a small-molecule inhibitor of protein phosphatase 2A (PP2A) to examine the enhancement of chemotherapy efficacy and the regulation of phosphorylation-dependent pathways.
Library Information
Target:
Phosphatase
Receptor:
PP2A
Pathways:
Metabolism
Plate Number:
AOCL-31
Plate Location:
b6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
<1 mg/mL; insoluble or slightly soluble)
Water Max Solubility:
49 mg/mL; 182.6 mM
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
