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Epothilone B
Cat. No.:
OB0626WX-2695
Appearance:
Crystalline solid
Purity:
≥95%
Identity:
Confirmed by IR, TLC, and HPLC.
Size:
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Product Overview
Description:
Epothilone B is a macrocyclic mycotoxin that induces the formation of hyperstable tubulin polymers and bundles of intracellular microtubules within non-mitotic systems. By systematically disrupting microtubule dynamics, this potent cytostatic agent arrests the cell cycle at the G2-M transition phase, making it a critical chemical tool for evaluating mitotic arrest across diverse drug-resistant cancer lineages.
Synonyms:
7S,11S-dihydroxy-8,8,10R,12S,16R-pentamethyl-3S-[(1E)-1S-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; Epo B; Epothilon B; Patupilone; 152044-54-7
CAS No.:
152044-54-7
Compound CID:
448013
Formula:
C27H41NO6S
Formula Weight:
507.7
Specification
λmax:
212 nm nm; 250 nm
Solubility in DMSO:
30 mg/mL
Solubility in Ethanol:
30 mg/mL
Storage:
Storage at -20°C.
Applications:
Epothilone B serves as a research tool for studying microtubule-associated cellular processes and bioactive natural product mechanisms. It supports cytoskeletal biology research, compound interaction studies, and characterization of complex secondary metabolites.