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Cyclopamine
Cat. No.:
0225LY-0543
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
Cyclopamine is a jerveratrum-type steroidal alkaloid that acts as a Smoothened (Smo) antagonist, demonstrating an IC50 of 46 nM in TM3Hh12 cells.
Synonym:
11-Deoxojervine; 4449-51-8; [3H]-Cyclopamine; (3H)-Cyclopamine; Veratraman-3-ol, 17,23-epoxy-, (3beta,23beta)-; (3beta23R)-17,23-Epoxyveratraman-3-ol; (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
CAS No.:
4449-51-8
Compound CID:
442972
Formula:
C27H41NO2
Formula Weight:
411.62
Specification
Targets&IC50:
Smo: 46 nM (TM3Hh12 cells)
Relative Density:
1.14 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Cyclopamine can be used in teratology and cancer research to study the antagonism of the Hedgehog signaling pathway.
Library Information
Target:
Smo
Receptor:
Smo
Pathways:
Metabolism; Stem cell regulation; GPCR/G protein signaling
Plate Number:
AOCL-8
Plate Location:
a7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
4.12 mg/mL; 10.01 mM
