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AGI-6780
Cat. No.:
OB0225WX-2675
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
AGI-6780 is a selective small molecule inhibitor that targets the IDH2 R140Q mutant with a potent IC50 of 23 nM.
Synonym:
1432660-47-3; AGI6780; N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide; AGI 6780; 1-[5-(Cyclopropylsulfamoyl)-2-Thiophen-3-Yl-Phenyl]-3-[3-(Trifluoromethyl)phenyl]urea; 1-[5-(cyclopropylsulfamoyl)-2-thiophen-3-ylphenyl]-3-[3-(trifluoromethyl)phenyl]urea; 3-(5-(cyclopropylsulfamoyl)-2-(thiophen-3-yl)phenyl)-1-(3-(trifluoromethyl)phenyl)urea; 3-[5-(cyclopropylsulfamoyl)-2-(thiophen-3-yl)phenyl]-1-[3-(trifluoromethyl)phenyl]urea; QCR-283; N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide; N-Cyclopropyl-4-(thiophen-3-yl)-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)benzene-1-sulfonamide
CAS No.:
1432660-47-3
Compound CID:
71299339
Formula:
C21H18F3N3O3S2
Formula Weight:
481.51
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AGI-6780 is utilized in biochemical research as a selective inhibitor of the mutant IDH2 R140Q enzyme to study the differentiation of malignant cells and the regulation of cellular metabolic flux.
Library Information
Target:
Dehydrogenase
Receptor:
IDH2
Pathways:
Metabolism
Plate Number:
L6700-08
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
96 mg/mL; 199.37 mM
Ethanol Max Solubility:
96 mg/mL
ALogP:
4.046
HBA_Count:
3
HBD_Count:
3
Rotatable Bond:
7
