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25-hydroxy Cholesterol-d2
Cat. No.:
OB0626WX-92
Appearance:
Solid
Purity:
≥99% (deuterated forms, d1-d2)
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
25-hydroxy Cholesterol-d2 is a deuterated stable isotope standard engineered for the precise quantitative mass spectrometry analysis (GC-MS or LC-MS) of native 25-hydroxy cholesterol. The corresponding unlabeled oxysterol is biosynthesized from cholesterol via cholesterol-25-hydroxylase—a pathway highly inducible by pro-inflammatory signals and viral infection—where it suppresses endogenous cholesterol production by binding to insulin-induced gene (INSIG) anchoring proteins to halt the transport of sterol regulatory element binding proteins (SREBPs) to the Golgi apparatus.
Labeling:
Stable isotope-labeled
Synonyms:
(3S,8S,9S,10R,13R,14S,17R)-17-((R)-6-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7,7-d2-3-ol
Formula:
C27H44D2O2
Formula Weight:
404.7
Specification
Solubility in Other Solvents:
Chloroform: ≥10 mg/mL; Methanol: 1-10 mg/mL
Storage:
Storage at -20°C.
Applications:
25-hydroxy Cholesterol-d2 serves as a stable isotope-labeled oxysterol standard for quantitative analysis of cholesterol metabolites and lipidomic profiling. It supports isotope dilution workflows, mass spectrometry calibration, and investigation of oxysterol metabolism.