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11-deoxy Corticosterone-d8
Cat. No.:
OB0626WX-18
Appearance:
Liquid
Purity:
≥99% (deuterated forms, d1-d8)
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
11-deoxy Corticosterone-d8 is an isotope-labeled internal standard engineered for the precise mass spectrometry-based quantification (GC- or LC-MS) of 11-deoxy corticosterone. As an endogenous mineralocorticoid synthesized within the zona fasciculata and zona glomerulosa of the adrenal gland, 11-deoxy corticosterone (DOC) is a downstream metabolite of progesterone and a key precursor to both aldosterone and corticosterone; it is metabolically converted into the neuroactive steroid THDOC, a positive modulator of GABAA receptors that induces barbiturate-like effects in rats, and its circulating levels are dynamically upregulated 3.4-fold in obese and diabetic mice, modulated by naloxone or corticotropin-releasing hormone (CRH) injections, and suppressed by dexamethasone in cynomolgus monkeys.
Labeling:
Stable isotope-labeled
Synonyms:
21-Hydroxy-pregn-4-ene-3,20-dione-2,2,4,6,6,17,21,21-d8; DOC-d8; 21-Hydroxyprogesterone-d8; 55487-63-3; Deoxycorticosterone-d8; (8S,9S,10R,13S,14S,17S)-2,2,4,6,6,17-hexadeuterio-17-(2,2-dideuterio-2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
CAS No.:
55487-63-3
Compound CID:
90473442
Formula:
C21H22D8O3
Formula Weight:
338.5
Specification
Solubility in Ethanol:
Soluble in ethanol.
Storage:
Storage at -20°C.
Applications:
11-Deoxy Corticosterone-d8 serves as a deuterated analytical standard for quantitative steroid analysis and validation of LC-MS-based measurement workflows. It supports accurate steroid profiling, signal normalization, and investigation of steroid biosynthetic pathway intermediates.