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NTRK2 Gene Test Service

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Overview

Protheragen has revealed through scientific studies the central role of Genetic Factors in the pathogenesis of obesity, in particular the effect of variants in the NTRK2 gene on physiological processes such as energy metabolism, appetite regulation, and fat deposition in individuals. NTRK2 variants are closely associated with key physiological functions such as weight regulation, energy expenditure, and control of eating behavior. We utilize high-precision molecular diagnostic techniques to precisely identify specific variant loci in the NTRK2 gene of individuals, which may directly or indirectly affect their obesity risk.

We use cutting-edge technologies and bioinformatics to explore the core pathways and proteins involved in the regulation of obesity and metabolism, with the aim of customizing target-specific anti-obesity therapeutic solutions for our clients.

Unraveling the Mystery of Genetic Obesity: NTRK2 Gene Testing

Full Variation Analysis

Our service aims to accurately identify NTRK2 gene variants associated with metabolic diseases such as obesity and diabetes through advanced gene sequencing technology. We provide deep sequencing services for the NTRK2 gene to analyze the variants of this gene, including but not limited to in-depth and detailed sequence analysis of the coding region of the NTRK2 gene to reveal variants such as single-nucleotide polymorphisms (SNPs), insertions, or deletions that lead to altered function. Through these high-precision analysis services, we help clients better understand how NTRK2 gene variants affect biological functions and obesity susceptibility.

Assessment of Potassium Ion Uptake

In further exploring the functional properties of the NTRK2 gene, we have focused on assessing its specific impact on the potassium ion uptake process. Through advanced experimental techniques and bioinformatics approaches, our researchers simulate and analyze how NTRK2 gene variants interfere with the function or regulatory mechanisms of potassium ion channels, thereby revealing the potential role of these variants in related diseases, especially those involving electrolyte balance disorders.

Multi-Gene Combined Testing

Our company not only focuses on the NTRK2 gene but also closely integrates the results of other genetic tests that are known to be closely associated with obesity. Combined with specialized bioinformatics tools and database resources, our bioinformatics team conducts in-depth mining and analysis of sequencing results to assess the impact of genetic variants on the risk of obesity and other diseases.

Workflow

Schematic of NTRK2 gene analysis. (Protheragen)

Applications

  • Metabolic disease association studies: Our specialized testing services can be used to explore the relationship between the NTRK2 gene and metabolic diseases such as metabolic syndrome, type 2 diabetes, etc.
  • Drug discovery support: Functional research based on the NTRK2 gene, providing a scientific basis for new drug development.
  • Obesity risk management: Through this service, we are not only able to help individuals understand their potential genetic predisposition to obesity but also to develop scientific diet and exercise programs to promote weight management more effectively and reduce the risk of related chronic diseases.

Advantages of Us

  • Identification of potential variants: Our company uses high-throughput sequencing technology to comprehensively analyze the NTRK2 gene and its associated regions to identify potential genetic variants.
  • Comprehensive risk assessment: Our company offers a combination of obesity genes to provide a comprehensive genetic risk assessment.
  • Our researchers are experienced in sample processing and data parsing to ensure that the extract concentration, purity, and integrity meet the requirements of subsequent experiments.

Publication Data

Journal: BMC Pregnancy and Childbirth

Published: 2023

IF: 3.1

Results: In this literature, the authors used a case-control study approach to explore the relationship between different expression profiles of the NTRK2 gene and birth weight. NTRK2 gene expression levels were significantly upregulated in low birth weight infants compared to normal birth weight infants. This finding suggests that NTRK2 gene expression may be associated with birth weight, which in turn may be associated with subsequent risk of obesity and diabetes.

Fig.1 Linear regression between birth weight and obesity and diabetes genes. Fig.1 Linear regression plot between birth weight, obesity, and diabetes genes. (Cheshmeh, et al., 2023)

Frequently Asked Questions

  1. What is the NTRK2 gene?

    The NTRK2 gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family, a membrane-bound receptor that primarily regulates brain-derived neurotrophic factor (BDNF) and regulates energy homeostasis downstream of the melanocortin 4 receptor. In addition, NTRK2 is involved in the MAPK pathway and cell differentiation processes. It plays an important physiological function in the human body and is associated with energy homeostasis, body weight regulation, and the possible pathogenesis of obesity.

  2. What diseases is the NTRK2 gene associated with?

    The NTRK2 gene is associated with sudden infant death syndrome, infantile myofibromatosis, alzheimer disease, epilepsy and bipolar disorder, lipofibromatosis-like neural tumor, toxic encephalopathy, malignant giant cell tumor of the tendon sheath, peripheral nervous system disease, childhood fibrosarcoma, schizophrenia, Christianson syndrome, and so on. If you are interested in the correlation between this gene and other diseases, we offer you a personalized analysis.

Protheragen provides high-quality genetic testing and data analysis services to help clients fully explore the mechanisms of obesity development. Please feel free to contact us for further information!

Reference

  1. Cheshmeh, S.; et al. Birth weight concerning obesity and diabetes gene expression in healthy infants; a case-control study. BMC Pregnancy and Childbirth. 2023, 23(1): 218. (CC BY 4.0)

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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