Overview of Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B (DYRK1B) Gene

Protheragen focuses on providing clients with a full range of Obesity Causation Analysis services, especially for the in-depth exploration of Genetically Induced Obesity. We accurately identify obesity-related genetic variants through advanced genetic testing technology to advance our clients' programs. Mutations in the DYRK1B gene are associated with tumors and abdominal obesity-metabolic syndrome 3 (AOMS3). Our research team is committed to revealing the potential role of each gene in the development of obesity.

Your Most Reliable DYRK1B Gene Testing Partner

Relying on high-throughput sequencing and target capture technology, we provide highly efficient DYRK1B gene testing. To detect the DYRK1B gene precisely, our lab adopts a strict quality control process to ensure the accuracy of the test results.

Genetic Engineering

Our lab provides custom models to meet the needs of clients. We have developed a range of animal models that allow for the in-depth study of the DYRK1B gene's impact on obesity. Utilizing these models, we simulate the effects of various genetic mutations, providing valuable insights into the pathogenesis of abdominal obesity and metabolic syndrome.

Sequencing

• Exome sequencing
  • Our researchers use probe hybridization to enrich the genomic sequence of exonic regions, combined with high-throughput sequencing to detect genetic mutations associated with protein function variation to evaluate the DYRK1B gene.
  • Our company provides exon sequencing services for each individual to analyze the effect of DYRK1B gene variants on abdominal fat distribution. Moreover, our bioinformatics team provides data annotation services to help clients browse the sequence of information.
• Genotyping and analysis of linkage
  • Our lab provides professional DNA sample collection, target sequence capture, sequencing, and functional analysis services.
  • We provide expression assay services for mutant and unmutated DYRK1B genes. Moreover, our company provides DYRK1B gene knockout cell models, such as the assessment of the effect of knockout of the DYRK1B gene on the lipogenic differentiation of the 3T3-L1 preadipocyte cell line.

Workflow

Our company provides one-stop gene sequencing services from sample collection to biological information analysis, providing clients with the most convenient solutions. Whether you want to analyze a mutation site or the signaling pathway of a candidate gene, our experienced researchers provide you with personalized services.

Applications

• The DYRK1B gene test provides detailed data support for single-gene disease or complex disease research.
• The DYRK1B gene test plays an important role in the study of tumor cell carcinogenesis and the AOMS3 mechanism.
• The DYRK1B gene test provides a new analytical pathway for the study of functional genetic variants and the pathogenesis of metabolic syndrome.
• The DYRK1B gene test can be used to study the mechanisms of lipid synthesis and glucose homeostasis.

Advantages of Us

• Our efficient computational team ensures fast and stable sequencing data analysis and delivery.
• Our company offers a very complete range of analytical services, including standard, advanced, and customized analyses.
• According to the client's research needs, our company supports different types of samples for testing and model customization.

Satisfactory One-Stop Obesity Research Program

Publication Data

Frequently Asked Questions

1. What is the DYRK1B gene?

   DYRK1B belongs to the Minibrain/Dyrk family of kinases. This family is mediated by arginine and activated by serine/threonine and regulates normal cell survival and differentiation. It encodes a nuclear protein kinase involved in cell cycle regulation, which may be abnormally expressed in tumor cells. In addition, there is variable splicing of the DYRK1B gene, forming multiple transcript variants.

2. What are the diseases associated with DYRK1B genes?

   DYRK1B gene-related diseases include, but are not limited to AOMS3, lung cancer, rhabdomyosarcoma, down syndrome, liver rhabdomyosarcoma, abdominal obesity-metabolic syndrome quantitative trait locus 2, intellectual developmental disorder, and autosomal dominant 7.

Combining high-throughput sequencing and powerful data parsing, Protheragen provides advanced memory testing services. Depending on the client's research needs, our company offers personalized analysis routes. No matter what questions you have, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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