Overview

Protheragen provides a comprehensive Obesity Causation Analysis Service to meet the research needs of our clients in various fields. Our research team has extensive experience in Genetically Induced Obesity research and provides clients with Monogenic Obesity Gene Test Services and Obesity Gene Panel Test Services. With cutting-edge genetic analysis, we precisely identify variants associated with the KIDINS220 gene that are linked to neuronal health, synaptic plasticity, and a wide range of neuropsychiatric and metabolic disorders, such as specific types of obesity.

Explore the Infinite Possibilities of KIDINS220 Gene

Our research team is dedicated to unraveling the specific mechanism of the role of the KIDINS220 gene in neurological development, functional maintenance, and pathological processes such as obesity. Through meticulous genetic screening, functional validation, and multi-omics analysis, we aim to provide our clients with cutting-edge scientific discoveries and personalized analysis strategies.

Gene Editing Animal Models

• Based on advanced gene editing technology, our company provides services to introduce or correct specific gene sequences in target animals. This process requires a high degree of specialized knowledge and delicate operation to ensure the accuracy and efficiency of gene editing.

Integrated Test

• Our company uses comprehensive analyses to verify whether gene editing affects the physiological, biochemical, and behavioral characteristics of animals as expected. This includes, but is not limited to, physiological marker analysis (e.g., blood glucose, blood pressure), behavioral tests (e.g., learning and memory abilities, anxiety and depressive states), and possible pathology.

Functional Analysis

• DNA collection and gene sequencing: Our researchers provide efficient and high-purity DNA sample isolation services. Deep sequencing is performed using high-throughput sequencing technologies (e.g., whole genome sequencing, exome sequencing, or targeted region sequencing) to obtain detailed gene sequence information. These data help to confirm the editing status of the target gene and also reveal potential off-target effects.
• Site mutation analysis: Based on the sequencing results, our data analysts use bioinformatics tools to perform precise mutation analysis of the target site, including determining the type of mutation (e.g., point mutation, insertion, or deletion), mutation frequency, and positional distribution.
• Signaling pathway analysis and validation: Our company deeply explores the effects of genetic mutations on specific signaling pathways to regulate the functions of organisms. We provide professional analysis of activation or inhibition of signaling pathways, expression level analysis, and secretion analysis of signaling pathway-related factors.

Workflow

We use gene editing technologies to accurately construct animal models and comprehensively test and evaluate the impact of gene editing. Our researchers collect DNA samples and analyze site mutations through high-throughput sequencing to explore the regulatory mechanisms of gene editing on organism functions and reveal the complex relationship between genes and biological functions.

Applications

• The KIDINS220 gene test can be used to identify individuals with specific genetic variants associated with hereditary obesity.
• An in-depth study of the function and regulatory mechanism of the KIDINS220 gene provides new targets for new drug development.
• The KIDINS220 gene plays an important regulatory role in neurological and metabolic disease research.

Advantages of Us

• Our company has strong sequencing and bioinformatic analysis capabilities to efficiently drive each project forward.
• Our company has experienced genetics experts to help clients deeply explain the functional mechanisms and effects of the KIDINS220 gene.
• Whether clients need a KIDINS220 gene test or a multi-gene assay, we offer personalized genetic analysis solutions.

Unlock Our Specialized Anti-Obesity Program

Publication Data

Frequently Asked Questions

1. What are the functions of the KIDINS220 gene?

   The KIDINS220 gene encodes a transmembrane protein expressed predominantly in the nervous system and is essential for neuronal cell survival, differentiation, and synaptic plasticity. The protein works in close collaboration with membrane receptors, cell signaling molecules, and cytoskeletal proteins, and serves as a bridge between neurotrophic proteins and other intracellular signaling pathways. The aberrant expression of the KIDINS220 gene has been strongly implicated in a variety of neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease. In addition, natural mutations in this gene can trigger a syndrome in which patients exhibit symptoms such as spastic paraplegia, mental retardation, nystagmus, and obesity.

2. What are the diseases associated with KIDINS220 genes?

   Diseases associated with the KIDINS220 gene include spastic paraplegia, intellectual disability, nystagmus, obesity (SINO), hydrocephalus, ventriculomegaly and arthrogryposis (VENARG), melanoma, paraplegia, cerebral palsy, and Coffin-Siris syndrome 9.

Protheragen is committed to promoting the development of obesity gene-related programs. We look forward to working with you to explore the mysteries of the KIDINS220 gene. If you are interested in the functional analysis of the KIDINS220 gene and its role in obesity-related diseases, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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