AdipoUpX™ Human UCP2 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human UCP2 MSCV Particle (Overexpression) is a high-titer, ready-to-use MSCV retroviral particle professionally engineered for the stable overexpression of the human UCP2 gene. It serves as a key regulator of mitochondrial reactive oxygen species and glucose-stimulated insulin secretion. The vector architecture is optimized for hematopoietic stem cells, stem cells, etc., providing a stable platform for in vitro functional validation. Product quality is ensured by comprehensive QC screening for contaminants, ensuring that your results in energy metabolism research are repeatable and safe.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: UCP2

Full Name: Uncoupling protein 2

Gene Symbol: UCPH; BMIQ4; SLC25A8

Gene ID: 7351

RefSeq ID-1: NP_001368872.1

RefSeq ID-2: NM_001381943.1

Summary: UCP2 encodes a mitochondrial protein that modulates cellular energy efficiency by uncoupling oxidative phosphorylation from ATP generation. Acting as part of the mitochondrial anion carrier protein family, UCP2 facilitates proton transport across the inner mitochondrial membrane, resulting in dissipation of the proton gradient as heat. This activity reduces mitochondrial membrane potential and influences metabolic flux. UCP2 is broadly expressed across tissues, with particularly high expression in skeletal muscle, and has been implicated in metabolic regulation, including thermogenesis, obesity, and diabetes. The gene is located adjacent to UCP3 within a conserved genomic cluster.

AdipoUpX™ Human UCP2 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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