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Salermide
Cat. No.:
OB0225WX-2755
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Salermide is a reverse amide derivative that functions as a strong inhibitor of Sirt1 and Sirt2, demonstrating higher inhibitory efficiency toward the Sirt2 isoform.
Synonym:
1105698-15-4; N-[3-[(2-Hydroxynaphthalen-1-yl)methylideneamino]phenyl]-2-phenylpropanamide; N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide; N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide; N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-alpha-methylbenzeneacetamide; N-(3-((2-Hydroxynaphthalen-1-yl)methyleneamino)phenyl)-2-phenylpropanamide; N-[3-[(2-oxo-1-naphthalenylidene)methylamino]phenyl]-2-phenylpropanamide; (E)-N-(3-(((2-hydroxynaphthalen-1-yl)methylene)amino)phenyl)-2-phenylpropanamide; N-(3-(((2-Hydroxynaphthalen-1-yl)methylene)amino)phenyl)-2-phenylpropanamide; N-{3-[(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino]phenyl}-2-phenylpropanamide
CAS No.:
1105698-15-4
Compound CID:
135659046
Formula:
C26H22N2O2
Formula Weight:
394.47
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Salermide is employed in epigenetic research as a potent inhibitor of SIRT1 and SIRT2 to investigate the induction of apoptosis in cancer cells through the modulation of sirtuin-mediated deacetylation.
Library Information
Target:
Sirtuin
Receptor:
SIRT1; SIRT2
Pathways:
DNA damage/DNA repair
Plate Number:
L6700-10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
78 mg/mL; 197.73 mM
Ethanol Max Solubility:
8 mg/mL
ALogP:
5.374
HBA_Count:
2
HBD_Count:
2
Rotatable Bond:
5
