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AZ20
Cat. No.:
0225LY-0592
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
AZ20 acts as a specific and high-efficiency inhibitor of ATR kinase, showing an IC50 of 5 nM in cell-free environments and demonstrating an 8-fold preference for ATR over mTOR.
Synonym:
1233339-22-4; AZ 20; (3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine; (R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine; 4-[4-(1-methanesulfonylcyclopropyl)-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl]-1H-indole; 1H-Indole, 4-[4-[(3R)-3-methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-; 4-{4-[(3r)-3-methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1h-indole; (3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methyl-morpholine
CAS No.:
1233339-22-4
Compound CID:
46244454
Formula:
C21H24N4O3S
Formula Weight:
412.51
Specification
Targets&IC50:
mTOR: 38 nM; ATR: 5 nM
Relative Density:
1.42 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AZ20 can be used in oncology research to explore the selective inhibition of ATR kinase and its role in increasing replication stress.
Library Information
Target:
ATM/ATR; mTOR
Receptor:
ATM/ATR; ATR; mTOR
Pathways:
PI3K/Akt/mTOR signaling; DNA damage/DNA repair
Plate Number:
AOCL-8
Plate Location:
f7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
50 mg/mL; 121.21 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
3 mg/mL; 7.27 mM
